Hellmuth Group

I am an independent researcher in molecular genetics at the University of Bayreuth. My research addresses the regulation of the human cell cycle, with a focus on mitotic surveillance mechanisms that safeguard genome integrity and ensure faithful chromosome segregation.
A central aspect of my work investigates how mitotic timing information is encoded through MDM2-dependent regulatory processes to enable p53 activation and G1 arrest following aberrant mitosis.

In parallel, I study how DNA double-strand breaks at human centromeres are resolved in a cell cycle–dependent manner and how this process supports CENP-A deposition and centromere maintenance during late mitosis.More broadly, my research encompasses DNA damage repair pathway choice, mitotic stress responses, intrinsic apoptosis, cohesin resolution dynamics, and cancer-relevant cell fate decisions.

Teaching and Supervision

I supervise and teach in the master specialisation module 'Cell Cycle & Cancer', coordinating the experimental course and leading the accompanying literature seminar. I also contribute to practical teaching in immunology and supervise multiple bachelor and master theses in molecular genetics and cell biology.

Academic Background

PhD (Dr. rer. nat.), University of Bayreuth
Postdoctoral research stay at Dana-Farber Cancer Institute / Harvard Medical School

Contact and Profiles

University of Bayreuth:
susanne.hellmuth@uni-bayreuth.de

https://orcid.org/0009-0002-0118-7164
susanne hellmuth - Google Scholar
https://doi.org/10.15495/EPub_UBT_00004919

Susanne Mellert
Technician
E-Mail: susanne.mellert@uni-bayreuth.de
Room: 7.1.02.09
Phone: +49(0)921 / 55-2709